Fig. 4

Classification of predicted frequency of severe anaemia (Hb < 7 g/dL, Hb < 5 g/dL) on day 7. Shown for Plasmodium falciparum malaria patients with G6PD deficiency in sub-Saharan Africa, treated with ACT (noPQ) or ACT + 0.25 mg/kg primaquine dose (PQ) shown for each value of baseline haemoglobin concentrations observed in G6PD-deficient population (y-axis). The results come from 100,000 simulated day 7 haemoglobin concentrations for each day 0 haemoglobin concentration value, age group, and transmission intensity from the AC7 model presented in Additional file 3: Table S12. Classification of AE frequency: very common ≥ 1/10, common ≥ 1/100 and < 1/10, uncommon ≥ 1/1000 and < 1/100, rare ≥ 1/10,000 and < 1/1000, and very rare < 1/10,000