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Table 4 Predictors of recovery from anaemia, multivariable Cox regression model with shared frailty term for study site

From: Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

  N n AHR 95% CI P-value
Baseline Hb (per 1 g/dL increase) 698 592 1.34 1.26, 1.42 < 0.001
Age      
 < 5 years 265 215 1.00   
 5–11 years 285 255 1.38a 1.14, 1.68 0.001
 12+ years 148 122 1.17b 0.88, 1.55 0.281
Hyperparasitaemiac      
 Yes 75 66 0.70 0.53, 0.93 0.012
 No 623 526 1.00   
  1. N number evaluated, n number with recovery observed
  2. aAHR 0.72, 95% CI 0.60–0.88 for comparison < 5 years old to 5–11 years old
  3. bAHR 0.86, 95% CI 0.65–1.14 for comparison < 5 year old to 12+ years old
  4. cDefined as parasitaemia > 100,000/μL and compared to patients with lower parasitaemia density (n = 468), community participants with no detectable parasitaemia (n = 23) or study participants with no detectable parasitaemia on enrolment but malaria-positive or gametocytaemic at screening (n = 132)