Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

Table 4 Predictors of recovery from anaemia, multivariable Cox regression model with shared frailty term for study site

	N	n	AHR	95% CI	P-value
Baseline Hb (per 1 g/dL increase)	698	592	1.34	1.26, 1.42	< 0.001
Age
< 5 years	265	215	1.00
5–11 years	285	255	1.38^a	1.14, 1.68	0.001
12+ years	148	122	1.17^b	0.88, 1.55	0.281
Hyperparasitaemia^c
Yes	75	66	0.70	0.53, 0.93	0.012
No	623	526	1.00

N number evaluated, n number with recovery observed
^aAHR 0.72, 95% CI 0.60–0.88 for comparison < 5 years old to 5–11 years old
^bAHR 0.86, 95% CI 0.65–1.14 for comparison < 5 year old to 12+ years old
^cDefined as parasitaemia > 100,000/μL and compared to patients with lower parasitaemia density (n = 468), community participants with no detectable parasitaemia (n = 23) or study participants with no detectable parasitaemia on enrolment but malaria-positive or gametocytaemic at screening (n = 132)

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