Skip to main content

Table 6 Risk factors for haemoglobinuria after treatment, multivariable logistic regression model with a random intercept for study site

From: Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

  N n AOR 95% CI P-value
G6PD status
 Normal 2038 32 1.00   
 Deficient 141 20 2.30 1.15, 4.60 0.018
Dose of PQa
(per 0.1 mg/kg)
2179 52 1.36 1.08, 1.72 0.010
Hyperparasitaemiab
 No 2046 45 1.00   
 Yes 133 7 3.92 1.38, 11.12 0.010
  1. N number evaluated, n number with haemoglobinuria
  2. aAOR = 2.47, 95% CI 1.25–4.89, P-value = 0.009, for comparison between target 0.25 mg/kg primaquine dose and no primaquine arms
  3. bDefined as parasitaemia > 100,000/μL; compared to patients with lower parasitaemia (n = 1468), no detectable (n = 523) or unknown parasitaemia (n = 55) in study participants who were malaria-positive or gametocytaemic at screening