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Table 4 Threshold effect analysis of serum 25(OH)D concentrations on all-cause and CVD mortality in OA patients

From: L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study

 

Adjusted HR (95% CI), P-value

All-cause mortality

 Fitting by the standard linear model

1.00 (0.99, 1.00) 0.31

 Fitting by the two-piecewise linear model

 

 Inflection point

54.40 nmol/L

 25(OH)D concentrations < 54.40 nmol/L

0.98 (0.96, 0.99) < 0.01

 25(OH)D concentrations ≥ 54.40 nmol/L

1.00 (1.00, 1.01) 0.40

P for Log-likelihood ratio

0.02

CVD mortality

 Fitting by the standard linear model

1.00 (0.99, 1.01) 0.84

 Fitting by the two-piecewise linear model

 

 Inflection point

27.70 nmol/L

 25(OH)D concentrations < 27.70 nmol/L

0.83 (0.72, 0.95) < 0.01

 25(OH)D concentrations ≥ 27.70 nmol/L

1.00 (0.99, 1.02) 0.56

P for log-likelihood ratio

0.02

  1. Adjusted for age, sex, race/ethnicity, survey cycle, education level, PIR, BMI, smoking status, alcohol consumption, disease duration of OA, and history of hypertension or diabetes