Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Table 1 Characteristics of the Kaiser Permanente Research Bank and UK Biobank study populations by ancestry group. Cases are individuals with multiple primary cancers or a single cancer (for UK Biobank only). Controls are those without any cancer

Population: Kaiser Permanente Research Bank
	Multiple-cancer cases						Controls
Ancestry	N	Mean age	Female (%)				N	Mean age	Female (%)
AFR	99	70.5	33.3				100	70.4	32.0
EAS	95	69.7	49.5				91	69.5	49.5
EUR	2,786	72.8	43.0				2,815	72.9	43.3
LAT	131	69.5	46.6				130	69.5	45.4
SAS	-	-	-				-	-	-
Population: UK Biobank
	Multiple-cancer cases			Single-cancer cases			Controls
Ancestry	N	Mean age	Female (%)	N	Mean age	Female (%)	N	Mean age	Female (%)
AFR	29	55.9	51.7	426	56.5	51.4	3,292	51.8	60.4
EAS	10	58.8	80.0	88	55.2	76.1	1,009	52.6	66.9
EUR	3,249	61.9	51.7	27,902	59.4	57.5	154,047	56.6	54.6
LAT	5	63.8	80.0	273	56.0	59.7	334	51.8	62.6
SAS	25	58.2	60.0	402	57.6	58.7	4,035	53.3	47.0

ISSN: 1741-7015