The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone

Table 1 Age and sex of study children at the time of the third, fourth (first booster) and fifth (second booster) doses of RTS,S/AS01_E during the study period, by intervention group

	SMC alone		RTS,S alone		Combined
	No.	%	No.	%	No.	%
Study year 1	N=1965		N=1988		N=1967
Received dose 1	1965	100	1988	100	1967	100
Received dose 2	1894	96.4	1911	96.1	1907	96.9
Received dose 3	1827	93.0	1860	93.6	1845	93.8
Mean age at dose 3 in months (SD)	14.4 (4.27)		14.5 (4.17)		14.4 (4.16)
Sex
Male	944/1827	51.7	965/1860	51.9	948/1845	51.4
Study year 2	N=1904		N=1927		N=1919
Received fourth dose	1798	94.4	1834	95.2	1835	95.6
Mean age at fourth dose in months (SD)	25.4 (4.28)		25.5 (4.16)		25.4 (4.19)
Sex
Male	931/1798	51.8	953/1834	52.0	948/1835	51.7
Study year 3	N=1847		N=1882		N=1873
Received fifth dose	1748	94.6	1776	94.4	1780	95.0
Mean age at fifth dose in months (SD)	37.5 (4.27)		37.6 (4.15)		37.5 (4.18)
Sex
Male	903/1748	51.7	922/1882	51.9	919/1873	51.6

For estimation of vaccine efficacy over time, the comparisons focus on the SMC alone and combined intervention groups (since the difference between these groups is that one received control vaccines and the other received RTS,S/AS01_E)
Abbreviation: RTS,S RTS,S/AS01_E

ISSN: 1741-7015