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Table 3 Unadjusted and adjusted differences in age at disease diagnoses in different ethnic groups using White ethnicity as the reference group, data from UK Biobank

From: Early onset of immune-mediated diseases in minority ethnic groups in the UK

  

Age/years

Unadjusted models

Adjusted modelsa

 

N (%)

mean (SD)

Coefficient

P-val.

(95% CI)

Coefficient

P-val.

(95% Cl)

Systemic lupus erythematosus

 White

888 (87.4)

49.8 (14.7)

Ref.

   

Ref.

   

 Mixed-race/Other

31 (3.1)

42.4 (12.6)

− 7.34

0.00

− 11.83

− 2.85

− 6.34

0.01

− 10.89

− 1.80

 African-Caribbean

60 (5.9)

43.8 (13.8)

− 5.99

0.00

− 9.60

− 2.39

− 5.53

<0.01

− 9.23

− 1.84

 South Asian

37 (3.6)

46.2 (14.5)

− 3.60

0.14

− 8.33

1.14

− 3.31

0.17

− 8.01

1.39

Vitiligo

 White

1016 (87.4)

48.7 (15.9)

Ref.

   

Ref.

   

 Mixed/other

35 (3.0)

50.2 (15.9)

1.52

0.57

− 3.78

6.83

0.80

0.76

− 4.37

5.97

 African-Caribbean

24 (2.1)

51.3 (10.8)

2.63

0.24

− 1.72

6.98

1.96

0.39

− 2.53

6.44

 South Asian

88 (7.6)

46.0 (14.5)

− 2.67

0.10

− 5.84

0.50

− 2.90

0.07

− 6.04

0.24

Rheumatoid arthritis

 White

11,173 (94.2)

55.7 (15.2)

Ref.

   

Ref.

   

 Mixed-race/Other

190 (1.6)

53.6 (14.9)

− 2.09

0.06

− 4.22

0.05

− 1.32

0.23

− 3.45

0.82

 African-Caribbean

206 (1.7)

54.5 (13.8)

− 1.17

0.23

− 3.06

0.73

− 0.55

0.58

− 2.48

1.38

 South Asian

296 (2.5)

54.1 (13.1)

− 1.56

0.04

− 3.07

− 0.04

− 1.31

0.09

− 2.84

0.21

Psoriasis

 White

14,466 (96.7)

45.1 (19.5)

        

 Mixed-race/Other

185 (1.2)

46.0 (15.7)

0.92

0.43

− 1.36

3.20

1.26

0.28

− 1.03

3.54

 African-Caribbean

55 (0.4)

48.6 (15.1)

3.50

0.08

− 0.48

7.48

3.23

0.11

− 0.77

7.23

 South Asian

260 (1.7)

48.6 (15.6)

3.49

0.00

1.56

5.41

3.32

<0.01

1.38

5.26

Pernicious anaemia

 White

3334 (93.6)

56.9 (12.7)

Ref.

   

Ref.

   

 Mixed-race/Other

24 (0.7)

52.0 (14.2)

− 4.81

0.09

− 10.40

0.78

− 3.73

0.15

− 8.86

1.41

 African-Caribbean

28 (0.8)

54.7 (12.7)

− 2.14

0.37

− 6.79

2.51

− 2.10

0.32

− 6.23

2.02

 South Asian

175 (4.9)

56.0 (11.5)

− 0.81

0.37

− 2.56

0.94

− 1.60

0.06

− 3.26

0.07

Myasthenia gravis

 White

465 (95.3)

57.3 (15.8)

Ref.

   

Ref.

   

 Mixed-race/Other

9 (1.8)

55.8 (6.0)

− 1.56

0.44

− 5.53

2.41

− 3.61

0.11

− 8.00

0.78

 African-Caribbean

10 (2.0)

51.6 (10.2)

− 5.74

0.07

− 11.95

0.48

− 3.54

0.20

− 9.01

1.93

 South Asian

4 (0.8)

62.8 (9.7)

5.41

0.21

− 3.03

13.86

5.93

0.32

− 5.81

17.67

Inflammatory bowel disease

 White

7252 (95.7)

48.9 (16.8)

Ref

   

Ref

   

 Mixed-race/Other

102 (1.4)

50.2 (16.0)

1.27

0.43

− 1.85

4.38

1.18

0.46

− 1.91

4.27

 African-Caribbean

58 (0.8)

50.6 (13.4)

1.64

0.35

− 1.81

5.09

0.90

0.62

− 2.63

4.42

 South Asian

163 (2.2)

49.2 (15.1)

0.26

0.83

− 2.08

2.61

− 0.03

0.98

− 2.39

2.34

Coeliac

 White

4609 (97.3)

56.3 (13.8)

Ref.

   

Ref.

   

 Mixed-race/Other

50 (1.1)

53.3 (11.2)

− 3.01

0.06

− 6.11

0.10

− 3.01

0.06

− 6.17

0.14

 African-Caribbean

29 (0.6)

49.5 (15.5)

− 6.75

0.02

− 12.32

− 1.18

− 7.07

0.01

− 12.66

− 1.47

 South Asian

51 (1.1)

52.2 (11.5)

− 4.03

0.01

− 7.18

− 0.88

− 4.31

0.01

− 7.45

− 1.16

Multiple sclerosis

 White

2410 (97.9)

44.7 (12.5)

Ref.

   

Ref.

   

 Mixed-race/Other

25 (1.0)

42.6 (9.5)

− 2.08

0.27

− 5.77

1.60

− 2.32

0.21

− 5.98

1.34

 African-Caribbean

18 (0.7)

45.2 (9.1)

0.54

0.80

− 3.60

4.68

0.29

0.89

− 3.66

4.23

 South Asian

10 (0.4)

51.3 (18.0)

6.62

0.22

− 3.97

17.20

7.00

0.19

− 3.55

17.55

Sjogren’s syndrome

 White

1015 (93.4)

64.4 (9.0)

Ref.

   

Ref.

   

 Mixed-race/Other

6 (0.6)

63.7 (7.4)

− 0.71

0.80

− 6.18

4.75

− 0.32

0.91

− 5.73

5.09

 African-Caribbean

27 (2.3)

57.6 (10.1)

− 6.75

0.00

− 10.54

− 2.97

− 5.76

<0.01

− 9.54

− 1.99

 South Asian

39 (3.6)

63.5 (9.3)

− 0.84

0.58

− 3.79

2.11

− 0.40

0.80

− 3.40

2.61

Autoimmune inflammatory diseases combined (ADs)

 White

42,664 (95.4)

50.0 (17.4)

Ref.

   

Ref.

   

 Mixed-race/Other

611 (1.4)

49.4 (15.2)

− 0.60

0.33

− 1.82

0.62

− 0.40

0.52

− 1.62

0.81

 African-Caribbean

459 (1.0)

50.8 (14.2)

0.79

0.24

− 0.52

2.09

0.58

0.39

− 0.73

1.88

 South Asian

1009 (2.3)

51.0 (14.5)

0.97

0.04

0.06

1.88

0.92

0.05

0.01

1.83

  1. aAdjusted for sex, deprivation, BMI categories and smoking status