NeRD: a multichannel neural network to predict cellular response of drugs by integrating multidimensional data

Table 2 Cell-line blind test

Method	\(CC_{p}\uparrow\)	\(R^{2}\uparrow\)	\(RMSE\downarrow\)	\(CC_{s}\uparrow\)
LR	0.231±0.0040	0.053±0.0020	0.171±0.0004	0.233±0.0039
SVR-L	0.110±0.0663	0.045±0.0206	0.180±0.0018	0.106±0.0634
SVR	0.471±0.0168	0.218±0.0169	0.153±0.0034	0.496±0.0015
RF	0.677±0.0351	0.440±0.0506	0.141±0.0044	0.566±0.0344
MLP	0.804±0.0144	0.658±0.0244	0.110±0.0040	0.767±0.0120
CNN	0.819±0.0124	0.671±0.0208	0.101±0.0034	0.781±0.0133
SRMF	0.836±0.0091	0.699±0.0151	0.096±0.0024	0.808±0.0093
VAE+MLP	0.796±0.0108	0.623±0.0187	0.108±0.0026	0.755±0.0102
DeepCDR	0.714±0.0568	0.506±0.0771	0.123±0.0094	0.586±0.1103
CDRScan	0.815±0.0123	0.663±0.0202	0.102±0.0034	0.788±0.0107
tCNNS	0.826±0.0156	0.682±0.0264	0.099±0.0044	0.791±0.0143
GraphDRP	0.833±0.0140	0.693±0.0228	0.097±0.0039	0.801±0.0125
NeRD	0.838\(\pm\)0.0132	0.702\(\pm\)0.0229	0.096\(\pm\)0.0039	0.808\(\pm\)0.0114

ISSN: 1741-7015