Table 1 Critical parameters from Target Product Profiles used to rank candidates in clinical development

1. Setting — Has the drug been trialled for this indication in high-income country settings only, low-middle-income country settings only or both?

2. Efficacy — In the available trials for this indication, has the drug demonstrated a clinically significant effect on the efficacy outcome/s?

3. Need for a companion diagnostic test — In the available trials for this indication, has the drug required the routine use of a companion diagnostic test?

4. Need for clinical monitoring — In the available trials for this indication, has the drug required the use of routine monitoring, or additional clinical monitoring?

5. Safety — In the available trials for this indication, has the drug demonstrated any safety concerns?

6. Mode of administration — In the available trials for this indication, what is the mode of administration? If no trials have been completed, what is the mode of administration for repurposed drugs?

7. Treatment adherence — In the available trials for this indication, what has been the adherence to treatment?

8. Stability — Is cold chain required for this product?

9. WHO Essential Medicines List — Is the product currently listed on the WHO Essential Medicines List or not?