Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles

Table 2 Summary of preclinical candidates for pre-eclampsia prevention

Drug subclass	Candidate	Summary	Archetype
Amino acid-peptide	l-Ergothione	Amino-acid supplement	Repurposed
Antioxidant	Hydrogen-rich saline	Alternative form of molecular hydrogen	Repurposed
Enzyme inhibitors (statins)	Simvastatin	Antilipemic agent from the statin family of drugs	Repurposed
Enzyme inhibitors (statins)	Lovastatin^a	Antilipemic agent from the statin family of drugs	Repurposed
Hydrogen sulphide donors	AP39^a	Mitochondrial-targeted small molecule	New
Hydrogen sulphide donors	MZe786	Sulphide-releasing aspirin	New
Macronutrients	Trehalose^a	Disaccharide	Repurposed
Polyphenol	Grape seed extract	Supplement high in polyphenols	Repurposed
	Mangiferin	Non-steroidal phytopolyphenol molecular extracted from mangoes	Repurposed
	Quercetin^a	Plant flavonoid high in polyphenols	Repurposed
	Scutellaria baicalensis root extract	Traditional Chinese medicinal plant extract	Repurposed
	Uncaria rhynchophylla extract	Traditional Chinese medicinal plant extract	Repurposed
	Vitexin	Flavonoid high in polyphenols	Repurposed
	Vitis labrusca/vinifera extract	Extract of the common grape vine	Repurposed
DNA, siRNA, mRNA	Ad-VEGF [viral vector delivery]^a	Growth factor that stimulates blood vessel formation	New
Small molecule	TRV027	AT1 receptor agonist	New

ISSN: 1741-7015