Table 2 Associations of risk factors with incident CVD by age at onset

Clinical risk factors

 Current smoker

1.49(1.33–1.67)

1.28(1.18–1.38)

1.15(1.05–1.25)

1.08(0.91–1.29)

0.0006

 Current drinker

0.82(0.73–0.92)

0.74(0.68–0.80)

0.82(0.75–0.90)

0.85(0.75–0.96)

0.8373

 Physical inactivity

1.21(1.05–1.38)

1.12(0.97–1.31)

1.14(0.99–1.31)

1.12(1.00–1.28)

0.0844

 Hypertension

3.77(3.34–4.25)

2.61(2.41–2.82)

2.27(2.08–2.48)

1.59(1.43–1.78)

 < 0.0001

 Diabetes

4.08(3.47–4.80)

2.35(2.13–2.59)

2.08(1.87–2.31)

1.36(1.18–1.58)

 < 0.0001

 Dyslipidemia

1.62(1.45–1.82)

1.35(1.25–1.46)

1.25(1.15–1.35)

1.12(1.01–1.25)

 < 0.0001

 Metabolism syndrome

3.38(2.94–3.88)

2.22(2.03–2.42)

1.77(1.61–1.94)

1.40(1.24–1.58)

 < 0.0001

 BMI, per SD increment

1.30(1.25–1.36)

1.24(1.20–1.29)

1.10(1.06–1.15)

1.12(1.06–1.17)

 < 0.0001

 Overweight or obese

1.71(1.52–1.92)

1.42(1.31–1.53)

1.19(1.10–1.29)

1.19(1.07–1.32)

 < 0.0001

 Systolic BP, per SD increment

2.22(2.12–2.34)

1.73(1.67–1.78)

1.58(1.52–1.63)

1.24(1.18–1.30)

 < 0.0001

 Diastolic BP, per SD increment

1.88(1.80–1.96)

1.47(1.42–1.51)

1.27(1.22–1.32)

1.09(1.03–1.15)

 < 0.0001

Lipids, per SD increment

 Total cholesterol

1.33(1.27–1.38)

1.10(1.06–1.14)

1.07(1.03–1.12)

1.07(1.02–1.13)

 < 0.0001

 Triglycerides

1.15(1.11–1.19)

1.10(1.07–1.13)

1.08(1.05–1.12)

1.09(1.03–1.15)

0.0193

 LDL cholesterol

1.05(0.98–1.14)

1.01(0.97–1.06)

1.04(1.00–1.08)

1.03(0.99–1.08)

0.8382

 HDL cholesterol

1.14(1.07–1.21)

1.04(1.00–1.09)

1.04(1.00–1.08)

0.98(0.93–1.03)

0.0023

 Total/HDL cholesterol

1.03(1.01–1.05)

1.04(1.00–1.07)

1.00(0.99–1.01)

1.01(1.00–1.02)

0.0549

 Triglycerides/HDL cholesterol

1.01(1.00–1.01)

1.14(1.09–1.19)

1.07(1.03–1.11)

1.04(1.01–1.07)

 < 0.0001

 Non–HDL cholesterol

1.32(1.26–1.38)

1.09(1.05–1.13)

1.06(1.01–1.10)

1.08(1.03–1.14)

 < 0.0001

 Remnant cholesterol

1.31(1.25–1.38)

1.08(1.04–1.12)

1.02(0.98–1.06)

1.05(0.99–1.10)

 < 0.0001

Metabolic, per SD increment

 Fasting blood glucose

1.31(1.24–1.38)

1.22(1.19–1.25)

1.16(1.13–1.19)

1.09(1.05–1.14)

 < 0.0001

 Triglyceride-glucose index

1.42(1.35–1.49)

1.26(1.22–1.31)

1.19(1.15–1.24)

1.14(1.09–1.21)

 < 0.0001

 eGFR

0.78(0.73–0.83)

0.79(0.75–0.84)

0.74(0.67–0.81)

0.96(0.85–1.09)

0.0030

 Creatinine

1.00(0.93–1.06)

1.04(1.01–1.07)

1.07(1.04–1.11)

1.04(1.00–1.08)

0.1459

 Serum uric acid

1.14(1.08–1.21)

1.10(1.05–1.14)

1.18(1.13–1.23)

1.07(1.02–1.12)

0.0076

Inflammatory, per SD increment

 Hs–CRP

1.12(1.08–1.17)

1.03(1.01–1.05)

1.06(1.03–1.09)

1.03(1.00–1.05)

0.0001

 White blood cell count

1.07(1.01–1.12)

1.00(0.99–1.01)

1.02(0.99–1.04)

0.97(0.94–1.00)

0.1470

 Neutrophil count

1.07(1.05–1.10)

1.03(1.01–1.04)

1.06(1.04–1.09)

1.00(0.97–1.03)

0.0248

 Platelet

1.00(0.99–1.00)

0.44(0.28–0.69)

0.68(0.37–1.24)

0.96(0.55–1.65)

0.0022

 Red blood cell count

0.00(0.00–0.86)

1.01(0.98–1.04)

1.01(0.98–1.04)

0.97(0.94–1.00)

0.0708