| HAIC 2d (n=113) |  | HAIC 1d (n=113) |  | p | p for grade 3–4 AE | ||||
---|---|---|---|---|---|---|---|---|---|---|
Any grade | Grades 1–2 | Grade 3 | Grade 4 | Any grade | Grades 1–2 | Grade 3 | Grade 4 |  |  | |
Hypertension | 40 (35.4%) | 39 (34.5%) | 1 (0.9%) | 0 | 46 (40.7%) | 44 (38.9%) | 2 (1.8%) | 0 | 0.41 | 1.0 |
Fatigue | 80 (70.8%) | 80 (70.8%) | 0 | 0 | 45 (39.8%) | 44 (38.9%) | 1 (0.9%) | 0 | <0.001 | 1.0 |
Fever | 16 (14.2%) | 16 (14.2%) | 0 | 0 | 4 (3.5%) | 4 (3.5%) | 0 | 0 | 0.005 | Â |
Sensory neuropathy | 42 (37.2%) | 42 (37.2%) | 0 | 0 | 12 (10.6%) | 11 (9.7%) | 1 (0.9%) | 0 | <0.001 | 1.0 |
Edema | 15 (13.3%) | 15 (13.3%) | 0 | 0 | 8 (7.1%) | 7 (6.2%) | 1 (0.9%) | 0 | 0.12 | 1.0 |
Alopecia | 23 (20.4%) | 23 (20.4%) | 0 | 0 | 4 (3.5%) | 4 (3.5%) | 0 | 0 | <0.001 | Â |
Abdominal pain | 64 (56.6%) | 63 (55.8%) | 1 (0.9%) | 0 | 60 (53.1%) | 57 (50.4%) | 2 (1.8%) | 1 (0.9%) | 0.59 | 0.62 |
Nausea | 84 (74.3%) | 82 (72.6%) | 2 (1.8%) | 0 | 62 (54.9%) | 59 (52.2%) | 3 (2.7%) | 0 | 0.002 | 1.0 |
Vomit | 46 (40.7%) | 39 (34.5%) | 7 (6.2%) | 0 | 33 (29.2%) | 29 (25.7%) | 4 (3.5%) | 0 | 0.07 | 0.35 |
diarrhea | 29 (25.7%) | 24 (21.2%) | 5 (4.4%) | 0 | 19 (16.8%) | 19 (16.8%) | 0 | 0 | 0.10 | 0.06 |
Neutropenia | 21 (18.6%) | 19 (16.8%) | 1 (0.9%) | 1 (0.9%) | 12 (10.6%) | 10 (8.9%) | 2 (1.8%) | 0 | 0.09 | 1.0 |
Anemia | 79 (69.9%) | 78 (69.0%) | 1 (0.9%) | 0 | 66 (58.4%) | 66 (58.4%) | 0 | 0 | 0.071 | 1.0 |
Thrombocytopenia | 56 (49.6%) | 54 (47.8%) | 2 (1.8%) | 0 | 45 (39.8%) | 38 (33.6%) | 4 (3.5%) | 3 (2.7%) | 0.14 | 0.17 |
Elevated ALT | 81 (71.7%) | 68 (60.2%) | 13 (11.5%) | 0 | 73 (64.6%) | 68 (60.2%) | 5 (4.4%) | 0 | 0.25 | 0.049 |
Elevated AST | 112 (99.2%) | 73 (64.6%) | 37 (32.7%) | 2 (1.8%) | 105 (92.9%) | 82 (72.6%) | 20 (17.7%) | 3 (2.7%) | 0.041 | 0.017 |
Hyperbilirubinemia | 55 (48.7%) | 54 (47.8%) | 1 (0.9%) | 0 | 50 (44.3%) | 48 (42.5%) | 2 (1.8%) | 0 | 0.51 | 1.0 |
Elevated CRE | 11 (9.7%) | 11 (9.7%) | 0 | 0 | 27 (23.9%) | 27 (23.9%) | 0 | 0 | 0.004 | Â |
Hypoalbuminemia | 104 (92.0%) | 104 (92.0%) | 0 | 0 | 104 (92.0%) | 104 (92.0%) | 0 | 0 | 1.000 | Â |
Prolonged PT | 55 (48.7%) | 55 (48.7%) | 0 | 0 | 29 (25.7%) | 29 (25.7%) | 0 | 0 | <0.001 | Â |
Grade 3–4 AE |  |  | 55 (48.7%) |  |  | 40 (35.4%) |  | 0.043 |