Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

Table 4 The sensitivity to change of each domain of NMSS in patients with MSA

NMSS	Baseline to 1-year follow-up (n=246)			Baseline to 2-year follow-up (n=97)			1- to 2-year follow-up (n=97)
NMSS	Mean annual change	SD of the change	Standardized effect	Mean annual change	SD of the change	Standardized effect	Mean annual change	SD of the change	Standardized effect
D1: Cardiovascular	1.09	3.84	0.28	0.95	2.42	0.39	0.37	4.03	0.09
D2: Sleep/fatigue	0.52	6.66	0.08	1.08	3.55	0.30	1.87	6.91	0.27
D3: Mood/apathy	0.93	14.85	0.06	2.08	7.37	0.28	3.73	14.36	0.26
D4: Perceptual problems/hallucinations	0.42	1.75	0.24	0.29	0.87	0.34	0.12	2.33	0.05
D5: Attention/memory	1.01	4.38	0.23	1.22	2.29	0.53	1.34	2.82	0.47
D6: Gastrointestinal	2.01	5.14	0.39	1.56	2.63	0.59	1.92	5.06	0.38
D7: Urinary	1.09	9.82	0.11	3.16	3.79	0.83	5.72	7.31	0.78
D8: Sexual function	1.02	5.32	0.19	2.20	3.91	0.56	3.78	8.57	0.44
D9: Miscellaneous	0.51	4.24	0.12	0.52	2.71	0.19	0.69	5.47	0.13

NMSS Non-Motor Symptoms Scale, MSA multiple system atrophy, SD standard deviation

ISSN: 1741-7015