Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs

Table 1 Correlation between in vitro responses of Kenyan P. falciparum isolates to piperaquine and other antimalarials

Drug pair	Number of isolates	Correlation coefficient (r)	P-value
PPQ versus DHA	77	0.0840	0.4679
PPQ versus LM	80	−0.0579	0.6097
PPQ versus ART	80	0.0254	0.8230
PPQ versus CQ	80	0.0278	0.8068
DHA versus LM	77	0.2105	0.0662
DHA versus ART	77	0.4036	0.0003**
DHA versus CQ	77	0.0589	0.6111
LM versus ART	80	0.0602	0.5957
LM versus CQ	80	0.1328	0.2402
ART versus CQ	80	0.0092	0.9355

The correlation for each pair of drugs per isolate is based on IC₅₀ values
PPQ piperaquine, DHA dihydroartemisinin, LM lumefantrine, ART artemether, CQ chloroquine
** P < 0.05 consistent with statistically significant difference assessed by Spearman correlation coefficient analyses

ISSN: 1741-7015