Skip to main content

Table 2 Distribution of the outcomes among all singleton pregnancies resulting in livebirth in Sweden, by proton pump inhibitor (PPI) exposure

From: Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events

 

Total

PPI users

PPI non-users

 

N

%

N

%

N

%

Total

1,089,515

100.00%

14,787

1.40%

1,074,728

98.60%

Pre-eclampsia

Yes

35,791

3.30%

723

4.90%

35,068

3.30%

No

1,053,724

96.70%

14,064

95.10%

1,039,660

96.70%

Gestational diabetes

Yes

15,958

1.50%

475

3.20%

15,483

1.40%

No

1,073,557

98.50%

14,312

96.80%

1,059,245

98.60%

Preterm birth

Yes

50,765

4.70%

966

6.50%

49,799

4.60%

No

1,038,750

95.30%

13,821

93.50%

1,024,929

95.40%

Low Apgar score

Yes

12,834

1.20%

239

1.60%

12,595

1.20%

No

1,076,681

98.80%

14,548

98.40%

1,062,133

98.80%

Birthweight for gestational age

Small

24,690

2.30%

472

3.20%

24,218

2.30%

Average

1,027,099

94.20%

13,737

92.90%

1,013,362

94.30%

Large

37,726

3.50%

578

3.90%

37,148

3.50%

  1. *Comorbidities defined as at least one diagnosis of hypertension, diabetes mellitus, and hypo- or hyperthyroidism
  2. **Other drugs defined as at least one prescription of non-steroid anti-inflammatory drugs (NSAIDs), low-dose aspirin, or antibiotics 3 months before or during gestation