Fig. 3

Multivariable adjusted differences and 95% confidence intervals (CIs) in epigenetic age acceleration indicated by second-generation clocks associated with the composite score of variability in the overall population and by gender. EAA, epigenetic age acceleration. β-Coefficients were derived from models adjusted for age (continuous), gender (female or male, unless in gender-stratified analyses), education (high school degree level, yes/no), marriage status (yes/no), race (White/Black/others), drinking status (current/ever/never), smoking status (current/ever/never), physical activity (> 1 time per week/1–3 times per month/never), household income (in quartiles), body mass index, systolic blood pressure, and pulse rate (all continuous) in 2014/2016. P-values were adjusted using the Benjamini-Hochberg methods