Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Table 2 Number of cohorts, offspring, and NMR-derived metabolic traits included in each life course stage analysis

Age category	Pregnancy and perinatal complications
Age category	PE	GH	GD	PTB	SGA	LGA
Neonate^a
N-exposed/total (N-cohorts/traits)	89/3117 (2/76)	192/3120 (2/76)	223/1896 (2/76)	201/3225 (2/76)	227/2998 (2/76)	226/2997 (2/76)
Infancy^b
N-exposed/total (N-cohorts/traits)	53/1894 (2/135)	101/1897 (2/135)	135/1181 (2/135)	156/1963 (2/135)	141/1831 (2/135)	132/1822 (2/135)
Childhood^c
N-exposed/total (N-cohorts/traits)	130/6883 (2/148)	910/6774 (2/148)	45/6806 (2/148)	350/6908 (2/148)	331/6144 (2/148)	664/6447 (2/148)
Adolescence^d
N-exposed/total (N-cohorts/traits)	134/6117 (2/162)	538/7012 (3/162)	57/3320 (2/162)	429/7947 (3/162)	466/7137 (3/162)	943/7614 (3/162)
Adulthood^e
N-exposed/total (N-cohorts/traits)	154/5850 (3/156)	760/4135 (3/156)	50/2857 (2/156)	441/8925 (4/155)	313/6387 (2/160)	652/6727 (2/160)

PE pre-eclampsia, GH gestational hypertension, GD gestational diabetes, PTB preterm birth, SGA small for gestational age, LGA large for gestational age
^a Metabolic traits were assessed in cord blood in the BiB cohort (n=2499 offspring) and the BIS cohort (n=726 offspring)
^b NMR-derived metabolic traits were assessed at mean age 1.1 years (SD=0.1) in the BIS cohort (n=591) and at mean age 1.6 years (standard deviation (SD)=0.5) in the BiB cohort (n=1373)
^c NMR-derived metabolic traits were assessed at mean age 4.2 years (SD=0.3) in the BIS cohort (n=429) and at mean age 7.5 years (SD=0.2) in the ALSPAC cohort (n=6206)
^d NMR-derived metabolic traits were assessed at mean age 12.0 years (SD=0.4) in the CheckPoint cohort (n=898), at mean age 15.4 years (SD=0.3) in the ALSPAC cohort (n=2348), and at mean age 16.0 years (SD=0.4) in the NFBC1986 cohort (n=4614)
^e NMR-derived metabolic traits were assessed at mean age 22.0 years (SD=7.0) in the YFS cohort (SD=n=509), at mean age 24.5 years (SD=0.8) in the ALSPAC cohort (n=2256), at mean age 46.6 years (SD=0.6) in the NFBC1966 cohort (n=5137), and at mean age 67.8 years (SD=4.4) in the HBCS cohort (n=1057). Adult meta-analysis was done using NFBC1966 age 46.6 years results because of the bigger sample size at this; meta-analysis results did not differ when repeated using NFBC1966 age 31.2 years and so only the age 46 results are included

ISSN: 1741-7015