Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease

Table 2 All-cause and cause-specific mortality by MAFLD subgroup

	Death	Duration (PYs)	Incidence rate (per 1000 PY)	Hazard ratio (95% confidence interval)
	Death	Duration (PYs)	Incidence rate (per 1000 PY)	Age, sex adjusted	Multivariate^a
All-cause mortality
No MAFLD	240,245	58,587,451.25	4.10	1 (Ref.)	1 (Ref.)
MAFLD-diabetes	58,797	4,848,887.35	12.13	1.43 (1.42, 1.45)	1.61 (1.59, 1.63)
MAFLD-overweight/obese	101,136	25,961,930.93	3.90	0.84 (0.84, 0.85)	1.19 (1.18, 1.20)
MAFLD-lean	17,415	1,727,529.60	10.08	1.45 (1.45, 1.49)	1.36 (1.34, 1.38)
CVD-specific mortality
No MAFLD	45,670	58,587,451.25	0.78	1 (Ref.)	1 (Ref.)
MAFLD-diabetes	11,683	4,848,887.35	2.41	1.55 (1.51, 1.58)	1.61 (1.58, 1.65)
MAFLD-overweight/obese	19,718	25,961,930.93	0.76	0.94 (0.93, 0.96)	1.22 (1.19, 1.25)
MAFLD-lean	3191	1,727,529.60	1.85	1.51 (1.46, 1.57)	1.45 (1.40, 1.51)
Cancer-specific mortality
No MAFLD	84,720	58,587,451.25	1.45	1 (Ref.)	1 (Ref.)
MAFLD-diabetes	19,822	4,848,887.35	4.09	1.37 (1.34, 1.39)	1.31 (1.29, 1.33)
MAFLD-overweight/obese	41,763	25,961,930.93	1.61	0.95 (0.94, 0.96)	1.11 (1.09, 1.13)
MAFLD-lean	5907	1,727,529.60	3.42	1.36 (1.32, 1.40)	1.27 (1.23, 1.30)
Liver disease-related mortality
No MAFLD	12,824	58,587,451.25	0.22	1 (Ref.)	1 (Ref.)
MAFLD-diabetes	6626	4,848,887.35	1.37	2.99 (2.90, 3.08)	2.85 (2.75, 2.95)
MAFLD-overweight/obese	9535	25,961,930.93	0.38	1.28 (1.25, 1.32)	1.76 (1.70, 1.82)
MAFLD-lean	2305	1,727,529.60	1.33	3.24 (3.10, 3.39)	2.84 (2.72, 2.97)

Abbreviations: MAFLD Metabolic-associated fatty liver disease, CVD Cardiovascular disease, PY Person years
^aAdjusted for age, sex, body mass index, income, smoking, alcohol consumption, exercise, and Charlson Comorbidity Index score

ISSN: 1741-7015