Table 3 Results of the GWAS mega-analysis using multinomial logistic regression (leading SNPs, top five)

6

29364135

rs3128852

C/T

0.281

8.21×10⁻²⁵

OR5V1 (intronic)

- only DM vs. normal

1.079 (1.030–1.132)

5.81 × 10⁻⁴

- only CKD vs. normal

0.977 (0.934–1.024)

0.342

- DKD vs. normal

1.421 (1.296–1.572)

2.32 × 10⁻²⁴

- only CKD vs. only DM

0.905 (0.859–0.955)

2.28 ×10⁻⁴

- DKD vs. only DM

1.317 (1.226–1.416)

4.72 × 10⁻¹⁴

- DKD vs. only CKD

1.455 (1.351–1.567)

3.13 ×10⁻²³

9

97149910

rs117744700

G/C

0.249

8.28×10⁻¹⁰

HIATL1 (intronic)

- only DM vs. normal

0.950 (0.911–0.993)

0.030

- only CKD vs. normal

0.967 (0.926–1.017)

0.216

- DKD vs. normal

0.769 (0.725–0.818)

6.22 ×10⁻¹¹

- only CKD vs. only DM

1.020 (0.966–1.078)

0.481

- DKD vs. only DM

0.809 (0.745–0.879)

5.22 ×10⁻⁷

- DKD vs. only CKD

0.793 (0.729–0.863)

7.65 ×10⁻⁸

6

32565056

rs28366355

G/T

0.498

2.04×10⁻⁸

HLA-DRB1(dist=7443),

- only DM vs. normal

1.117 (1.070–1.169)

3.38 × 10⁻⁸

HLA-DQA1(dist=40127)

- only CKD vs. normal

1.085 (1.037–1.137)

1.46 × 10⁻⁴

(intergenic)

- DKD vs. normal

1.114 (1.040–1.201)

9.52×10⁻⁴

- only CKD vs. only DM

0.971 (0.925–1.018)

0.224

- DKD vs. only DM

0.998 (0.931–1.068)

0.941

- DKD vs. only CKD

1.027 (0.958–1.102)

0.448

11

100902053

rs1824125

A/C

0.248

6.58 × 10⁻⁷

PGR (UTR3)

- only DM vs. normal

1.075 (1.026–1.131)

1.50 × 10⁻³

- only CKD vs. normal

1.030 (0.981–1.084)

0.229

- DKD vs. normal

1.211 (1.114–1.327)

1.59 × 10⁻⁷

- only CKD vs. only DM

0.957 (0.907–1.012)

0.118

- DKD vs. only DM

1.126 (1.043–1.215)

2.14×10⁻³

- DKD vs. only CKD

1.176 (1.088–1.272)

4.58×10⁻⁵

2

206490310

rs75292524

A/G

0.283

7.82×10⁻⁷

PARD3B(dist=5424),

- only DM vs. normal

0.960 (0.921–1.002)

0.072

NRP2(dist=56914)

- only CKD vs. normal

0.991 (0.947–1.039)

0.720

(intergenic)

- DKD vs. normal

0.815 (0.768–0.867)

7.82×10⁻⁷

- only CKD vs. only DM

1.126 (1.043–1.215)

0.239

- DKD vs. only DM

0.848 (0.784–0.918)

4.06×10⁻⁵

- DKD vs. only CKD

0.822 (0.759–0.891)

1.59×10⁻⁶