Fig. 1
From: PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models
Regulation of target gene expression and signaling pathway in the selected cells under glucose deprivation-induced metabolic stress. A Whole gene variance on selected cells under glucose deprivation-induced metabolic stress. The x-axis indicates the count of genes in parental and selected cells under glucose-deprived conditions. B, C Bar plot showing 12 significantly enriched upregulated pathways in selected cells under glucose deprivation-induced metabolic stress. D Heatmap of RNA-Seq expression values of target genes in selected cells under glucose deprivation-induced metabolic stress. E Significantly enriched upregulated and downregulated calcium regulation-related target genes in selected cells. Control and test were normalized by the trimmed mean of M-values (TMM), implemented in the edgeR package. G(+) glucose present, G(−) glucose deprivation, FC fold change. F Protein–protein interaction network functional enrichment analysis indicated PGC1α, HNF4α, and NFκB interaction from the STRING database