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Table 1 Participant characteristics for the 3 studies included in Mendelian randomisation analyses

From: The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study

Characteristic

Category

ALSPAC (N = 7360)

BiB (N = 7433)

MoBa (N = 50,717)

Offspring

 CHD

Yes

61 (0.8)

81 (1.1)

420 (0.8)

 Sex

Male

3703 (50.3)

3818 (51.4)

25,729 (51.0)

Female

3657 (49.7)

3615 (48.6)

24,810 (49.0)

Maternal

 Age, years

 

29.2 (4.6)

27.4 (5.6)

30.2 (4.6)

 Parity

Primiparous

3257 (46.6)

2963 (40.1)

27,199 (53.6)

 BMI, kg/m2

 

22.5 (4.2)

26.2 (5.7)

24.1 (4.3)

 Ethnicity

White European

7360 (100.0) a

3084 (42.6)

50,717 (100.0) b

South Asian

-

3503 (48.4)

-

Other

-

656 (9.1)

-

 Any smoking during pregnancy

Yes

1679 (26.1)

1175 (18.1)

4175 (10.1)

 Any alcohol during pregnancy

Yes

4866 (79.9)

1040 (49.3)

12,602 (32.6)

  1. Data are means ± SD or n (%) unless stated. % are based on data available (data were not complete)
  2. Abbreviations: BiB, Born in Bradford; ALSPAC, Avon Longitudinal Study of Parents and Children; MoBa, Norwegian Mother, Father and Child Cohort Study; CHD, congenital heart disease; BMI, body mass index; kg, kilogrammes; m, metres
  3. aAll non-white European women with ethnicity data were not included in the analysis
  4. bIndividuals of non-European ancestries were removed based on principal component analysis
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BMC Medicine

ISSN: 1741-7015

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