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Table 4 Associations of remnant cholesterol with the increasing baPWV along with decreasing ABI beyond LDL-C in sensitivity analyses

From: Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol

 

Adjusted odds ratio (95% CI)

Sensitivity analysis I

Sensitivity analysis II

Sensitivity analysis III

RC concentration, + 10 mg/dL

1.220 (1.141–1.304)

1.176 (1.090–1.269)

1.256 (1.179–1.337)

Quartiles of RC

 Quartile 1

Reference

Reference

Reference

 Quartile 2

1.251 (0.980–1.597)

1.311 (1.024–1.679)

1.398 (1.125–1.737)

 Quartile 3

1.305 (1.017–1.675)

1.582 (1.239–2.020)

1.521 (1.228–1.884)

 Quartile 4

1.862 (1.448–2.394)

1.951 (1.527–2.493)

1.789 (1.443–2.217)

RC percentile minus LDL-C percentile

 Concordant

Reference

Reference

Reference

 Discordantly low RC

0.726 (0.585–0.901)

0.747 (0.598–0.934)

0.708 (0.583–0.862)

 Discordantly high RC

1.047 (0.839–1.306)

0.979 (0.785–1.221)

0.970 (0.798–1.179)

Cut-off: LDL-C 130 mg/dL; RC 24 mg/dL

 LDL-C < 130 mg/dL and RC < 24 mg/dL

Reference

Reference

Reference

 LDL-C ≥ 130 mg/dL and RC < 24 mg/dL

1.672 (1.085–2.578)

1.307 (0.896–1.907)

1.190 (0.928–1.525)

 LDL-C < 130 mg/dL and RC ≥ 24 mg/dL

1.446 (1.170–1.787)

1.395 (1.111–1.753)

1.381 (1.154–1.652)

 LDL-C ≥ 130 mg/dL and RC ≥ 24 mg/dL

1.559 (1.255–1.937)

1.385 (1.115–1.720)

1.606 (1.291–1.997)

Cut-off: LDL-C 100 mg/dL; RC 17 mg/dL

 LDL-C < 100 mg/dL and RC < 17 mg/dL

Reference

Reference

Reference

 LDL-C ≥ 100 mg/dL and RC < 17 mg/dL

1.561 (1.07–2.277)

1.259 (0.876–1.810)

1.233 (0.879–1.728)

 LDL-C < 100 mg/dL and RC ≥ 17 mg/dL

1.595 (1.154–2.205)

1.587 (1.129–2.231)

1.551 (1.146–2.100)

 LDL-C ≥ 100 mg/dL and RC ≥ 17 mg/dL

2.026 (1.522–2.696)

1.784 (1.331–2.391)

1.940 (1.489–2.527)

  1. Odds ratio (OR) was estimated by ordinal logistics regression models adjusted for age, sex, body mass index, smoking status, SBP, hypertension, diabetes, antihypertensive medication, lipid-lowering treatment
  2. Abbreviations: CI Confidence interval, RC Remnant cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, SBP Systolic blood pressure
  3. (i) Concordant was defined as RC percentile and LDL-C percentile within ± 10 percentile units; (ii) discordantly low RC was defined as LDL-C percentile > RC percentile by 10 percentile units; and (iii) discordantly high RC was defined as RC percentile > LDL-C percentile by 10 percentile units
  4. Sensitivity analysis I: Individuals (n = 634) on lipid-lowering medication (referring to statins and fibrates) excluded from the analysis
  5. Sensitivity analysis II: High-sensitivity C-reactive protein (hsCRP) was additionally adjusted
  6. Sensitivity analysis III: Change of systolic blood pressure during the follow-up period was additionally adjusted