Fig. 2

Forest plot of the Mendelian randomization analyses for the associations between circulating cytokines and risk of amyotrophic lateral sclerosis. Abbreviations: β-NGF, beta nerve growth factor; CI, confidence interval; CTACK, cutaneous T-cell attracting (CCL27); FGF-basic, basic fibroblast growth factor; G-CSF, granulocyte colony-stimulating factor; GRO-a, growth regulated oncogene-α (CXCL1); HGF, hepatocyte growth factor; IFN-γ, interferon-gamma; IL-1rα, interleukin-1 receptor antagonist; IL-1β, interleukin-1-beta; IL-2, interleukin-2; IL-2rα, interleukin-2 receptor, alpha subunit; IL-4, interleukin-4; IL-5, interleukin-5; IL-6, interleukin-6; IL-7, interleukin-7; IL-8, interleukin-8; IL-9, interleukin-9; IL-10, interleukin-10; IL-12p70, interleukin-12p70; IL-13, interleukin-13; IL-16, interleukin-16; IL-17, interleukin-17; IL-18, interleukin-18;IP-10, interferon gamma-induced protein 10 (CXCL10); MCP-1, monocyte chemotactic protein-1 (CCL2); MCP-3, monocyte specific chemokine 3 (CCL7); M-CSF, macrophage colony-stimulating factor; MIF, macrophage migration inhibitory factor; MIG, monokine induced by interferon-gamma; MIP-1α, macrophage inflammatory protein-1α (CCL3); MIP-1b, macrophage inflammatory protein-1β; OR, odds ratio; PDGF-bb, platelet derived growth factor BB; RANTES, regulated on activation, normal T-cell expressed and secreted (CCL5); SCF, stem cell factor; SCGF-β, stem cell growth factor beta; SDF-1α, stromal cell-derived factor-1 alpha; SNP, single nucleotide polymorphism; TNF-α, tumor necrosis factor-alpha; TNF-β, tumor necrosis factor-beta; TRAIL, TNF-related apoptosis inducing ligand; VEGF, vascular endothelial growth factor