Fig. 1

A–F Associations between parental prenatal metabolites and offspring weight up to 8 years of age. Results from linear spline mixed model analyses. Knots were placed at age 9 months and 5 years. P-values from the interaction between maternal or paternal metabolite level and offspring spline (age). The data were stratified to present regression coefficients (β) with one standard error on each side (thick error bars) and 95% confidence intervals (thin error bars) between the knots. Model 1 was adjusted for offspring age. Model 2 was adjusted for maternal or paternal BMI, smoking and offspring sex and age. Model 3 was adjusted for maternal or paternal metabolite level, BMI, smoking and offspring sex and age. TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; apo, apolipoprotein; w, weeks; m, months; y, years