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Table 3 HRs for the associations between intellectual disability (ID) and overall and type-specific CVD among all individuals born in Denmark between 1978 and 2016

From: Association of intellectual disability with overall and type-specific cardiovascular diseases: a population-based cohort study in Denmark

 

Individuals without ID

Individuals with ID

Model 1,

HR (95% CI)

Model 2,

HR (95% CI)

No. of CVD

Rate*

No. of CVD

Rate*

All

 Type-specific CVD

  Ischemic heart disease

3047

0.07

31

0.11

1.46 (1.03 to 2.08)

1.26 (0.87 to 1.81)

  Cerebrovascular disease

5065

0.12

88

0.31

2.65 (2.15 to 3.27)

2.50 (2.02 to 3.10)

  Stroke

3821

0.09

59

0.21

2.34 (1.81 to 3.03)

2.20 (1.69 to 2.86)

  Heart failure

974

0.02

25

0.09

3.81 (2.56 to 5.66)

3.56 (2.37 to 5.35)

  Atrial fibrillation

2013

0.05

19

0.07

1.33 (0.84 to 2.09)

1.26 (0.79 to 2.01)

  Hypertensive disease

122 714

2.92

982

3.61

1.32 (1.24 to 1.41)

1.30 (1.22 to 1.39)

  Deep vein thrombosis

3898

0.09

57

0.20

2.30 (1.77 to 2.98)

2.10 (1.60 to 2.75)

Male

 Overall CVD

37 339

1.72

374

2.25

1.30 (1.18 to 1.44)

1.26 (1.13 to 1.39)

 Type-specific CVD

  Ischemic heart disease

1925

0.09

15

0.09

1.00 (0.60 to 1.66)

0.92 (0.55 to 1.53)

  Cerebrovascular disease

2585

0.12

55

0.32

2.77 (2.12 to 3.62)

2.59 (1.98 to 3.40)

  Stroke

1990

0.09

34

0.20

2.22 (1.58 to 3.11)

2.06 (1.46 to 2.90)

  Heart failure

576

0.03

13

0.07

2.94 (1.70 to 5.09)

2.65 (1.49 to 4.70)

  Atrial fibrillation

1280

0.06

14

0.08

1.39 (0.82 to 2.35)

1.30 (0.75 to 2.24)

  Hypertensive disease

61,201

2.84

544

3.27

1.27 (1.17 to 1.38)

1.25 (1.15 to 1.36)

  Deep vein thrombosis

1186

0.05

15

0.09

1.60 (0.96 to 2.66)

1.44 (0.85 to 2.44)

Female

 Overall CVD

40 749

1.98

278

2.64

1.29 (1.14 to 1.45)

1.24 (1.10 to 1.39)

 Type-specific CVD

  Ischemic heart disease

1122

0.05

16

0.14

2.57 (1.57 to 4.21)

2.02 (1.19 to 3.43)

  Cerebrovascular disease

2480

0.12

33

0.30

2.46 (1.75 to 3.47)

2.34 (1.65 to 3.32)

  Stroke

1831

0.09

25

0.23

2.53 (1.71 to 3.76)

2.40 (1.60 to 3.60)

  Heart failure

398

0.02

12

0.11

5.60 (3.15 to 9.94)

5.43 (3.05 to 9.66)

  Atrial fibrillation

733

0.04

5

0.04

1.20 (0.50 to 2.89)

1.20 (0.50 to 2.89)

  Hypertensive disease

61,513

2.99

438

4.16

1.40 (1.28 to 1.54)

1.38 (1.25 to 1.51)

  Deep vein thrombosis

2712

0.13

42

0.38

2.72 (2.01 to 3.69)

2.50 (1.83 to 3.42)

  1. Model 1 adjusted for sex and calendar year; model 2 additionally adjusted for parity, maternal age, maternal education, maternal country of origin, maternal psychiatric disorders, and cardiovascular disorders before childbirth
  2. HR Hazard ratio, CI Confidence interval, CVD Cardiovascular disease
  3. *Per 1000 person-years
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