Fig. 4

Mitochondrial transplantation enhances early lactate normalization and mitigates lung injury after cardiac arrest and resuscitation. A Arterial lactate levels at pre-arrest baseline and 15- and 120-min post-resuscitation. n = 11 per group. A mixed-effects model for repeated-measures analyses, followed by one-way analysis of variance (ANOVA) with Šidák’s correction for post hoc comparisons, was used. B Cardiac arrest-induced lung edema at 72 h post-resuscitation was diminished by delivering freshly isolated mitochondria. C Left ventricular ejection fraction at pre-arrest baseline and 2 h post-resuscitation in post-arrest rats treated with vehicle, frozen-thawed mitochondria (frozen-thawed-mito), or freshly isolated mitochondria (fresh-mito). A mixed-effects model for repeated-measures analysis, followed by ANOVA with Šidák’s correction for post hoc comparisons, was employed. D Changes in the mean arterial pressure (MAP). A mixed-effects model for repeated-measures analysis, followed by ANOVA with Šidák’s correction for post hoc comparisons, was used. Data represent the mean ± standard deviation