Fig. 5

Dynamics of gene expression based on GEDI. Tile maps based on self-organizing maps are shown for all time points for monocytes, neutrophils, and whole blood. Each tile within a cell type represents the same set of genes across all 3 time points and VRFCs. Changes in color in a tile over the time points show changes in expression of the member genes over time, while constant color over the time points shows more constant expression levels. The asterisk (*) indicates tiles where immunoglobulin genes are present, and the plus (+) indicates the presence of interleukin receptor genes. On the right, gene density maps represent the number of DEGs per tile (genes clustered based on Pearson’s correlation). Tiles behaving similarly are placed in the same mosaic neighborhood. Letters on the tiles in the gene density map depict presence of specific cell markers in the DEGs in a specific tile (M: monocytes, G: granulocyte= neutrophils, basophils and eosinophils)