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Table 1 Subject demographics and relevant clinical characteristics in each of the time windows analyzed

From: Monocyte, neutrophil, and whole blood transcriptome dynamics following ischemic stroke

   

IS

VRFC

0–24 h (TP1)

24–48 h (TP2)

>48 h (TP3)

Monocytes

Subjects

12

17

13

5

Age, years (mean ±SD)

62.08±6.70

68.41±11.88

61.46±12.51

66.60±8.04

Time since event, h (mean ±SD)

nil

15.67±5.26

32.37±8.51

56.02±9.80

NIHSS at admission (mean ±SD)

0±0

4.94±5.40

2.92±4.51

3±2.16a

NIHSS at blood draw (mean ±SD)

1.6±3.57

3±4.27

1.76±4.08

1.75±0.95

Sex (male; female) (n)

6; 6

10; 7

8; 5

0; 5

Diabetes (n)

6

3

2

1

Hyperlipidemia (n)

10

6a

7

3

Hypertension (n)

6

13

10

5

Neutrophils

Subjects

12

16

12

5

Age, years (mean ±SD)

64.66±11.34

68.5±12.26

61.50±13.06

66.60±8.04

Time since event, h (mean ±SD)

nil

16.25±4.84

31.21±7.74

56.02±9.80

NIHSS at admission (mean ±SD)

0±0

4.62±5.41

3.08±4.67

3±2.16

NIHSS at blood draw (mean ±SD)

2.25±3.86

3.18±4.33

1.83±4.26

1.75±0.95

Sex (male; female) (n)

6; 6

9; 7

7; 5

0; 5

Diabetes (n)

6

3

1

1

Hyperlipidemia (n)

10

6a

6

3

Hypertension (n)

9

13

9

5

Whole blood

Subjects

18

18

13

6

Age, years (mean ±SD)

64.83±9.401

68.88±11.70

63.15±11.23

65.66±7.55

Time since event, h (mean ±SD)

nil

15.53±5.14

32.41±8.47

62.00±17.07

NIHSS at admission (mean ±SD)

0±0

4.72±5.32

2.92±4.51

3.20±1.92

NIHSS at blood draw (mean ±SD)

1.8±3.49

3±4.27

1.92±4.05

1.8±0.83

Sex (male; female) (n)

10; 8

11; 7

7; 6

0; 6a

Diabetes (n)

7

4

3

1

Hyperlipidemia (n)

14

7a

6

4

Hypertension (n)

11

14

10

6

  1. aSignificant difference vs. VRFC (p-value < 0.05, Fisher’s exact probability test—categorical variables, Student’s t test—continuous variables) NIHSS scale range is from 0 to 43. Less than half of VRFC had NIHSS assessed. For the rest of time points 80–100% of patients had NIHSS data