Fig. 1

Compound EGFR mutation-positive patients had fewer EGFR 19-Del mutations and more L858R and rare EGFR mutations. A The flowchart of the study. B Comparing the percentage of patients with single EGFR mutation (n = 7460) and compound EGFR mutations (n = 1025) according to their EGFR mutation type. Based on the dominant EGFR mutations, patients with compound EGFR mutations were divided into common (i.e., common + common, common + rare, or common + VUSs), rare (i.e., rare + rare or rare + VUSs), and VUSs (i.e., VUSs + VUSs) groups. C Comparing the percentage of patients with single EGFR mutation (n = 7460) and compound EGFR mutations (N = 998) according to their EGFR mutation type. Patients with concurrent L858R and 19-Del (n = 27) were not included in the analysis. D The difference of the accompanied EGFR mutations between 19-Del and L858R-containing compound EGFR mutations. Patients with concurrent L858R and 19-Del (n = 27) were not included in the analysis. NGS, next-generation sequencing; VUS, variants of uncertain significance; TM, transmembrane domain