Fig. 4

Sterile protection against PfNF135 mosquito bite challenge. A Kaplan–Meier curve depicting percentage of participants that remained sterilely protected after homologous challenge infection with PfNF135. Participants in the high-dose arm received three immunizations by bites of fifteen PfNF135-infected mosquitoes. Participants in the low-dose arm received three immunizations by bites of five infected mosquitoes with the same parasite strain. The control group received no immunizations. B Percentage of sterilely protected partially protected and unprotected participants after controlled human malaria infection with the homologous NF135 strain in each study arm. Participants in the high-dose arm received three immunizations by bites of fifteen P. falciparum NF135-infected mosquitoes and participants in the low-dose arm received three immunizations by bites of five infected mosquitoes with the same parasite clone. Mosq, mosquitoes