Table 3 Cumulative acute adverse events in safety population (n = 64)
|  | Grade 1–2 | Grade 3 | Grade 4 |
|---|---|---|---|
Hematologic | |||
 Anemia | 43 (67.2) | 5 (7.8) | 0 |
 Leukopenia | 33 (51.6) | 0 | 0 |
 Neutropenia | 24 (37.5) | 0 | 0 |
 Thrombocytopenia | 11 (17.2) | 4 (6.2) | 0 |
Non-hematologic | |||
 Hand-foot syndrome | 40 (62.5) | 2 (3.1) | 0 |
 AST increased | 38 (59.4) | 0 | 1 (1.6) |
 Proteinuria | 37 (57.8) | 4 (6.2) | 0 |
 Fatigue | 33 (51.6) | 7 (10.9) | 0 |
 Total bilirubin increased | 29 (45.3) | 4 (6.2) | 0 |
 Mucositis | 28 (43.8) | 8 (12.4) | 0 |
 Vomiting | 25 (39.1) | 1 (1.6) | 0 |
 Nausea | 24 (37.5) | 0 | 0 |
 Hyponatremia | 22 (34.4) | 6 (9.3) | 0 |
 Hemorrhage | 21 (32.8) | 2 (3.1) | 0 |
 Hypocalcemia | 21 (32.8) | 0 | 0 |
 Hypertension | 20 (31.3) | 9 (14.1) | 0 |
 Hypoalbuminemia | 19 (29.7) | 0 | 0 |
 Diarrhea | 17 (26.6) | 3 (4.7) | 0 |
 Creatinine increase | 16 (25.0) | 0 | 0 |
 Rash | 11 (17.2) | 0 | 0 |
 Allergic reactions | 11 (17.2) | 0 | 0 |
 Anorexia | 10 (15.6) | 0 | 0 |
 Constipation | 10 (15.6) | 0 | 0 |
 ALT increased | 10 (15.6) | 1 (1.6) | 0 |
 Hypokalemia | 8 (12.4) | 2 (3.1) | 0 |
 Fever | 7 (10.9) | 1 (1.6) | 0 |
 Hoarseness | 5 (7.8) | 0 | 0 |