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Fig. 8 | BMC Medicine

Fig. 8

From: Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

Fig. 8

Measurement of HIF-1α and sFIt-1/PIGF levels in maternal serum and A2M-manipulated HUASMCs. a Schematic illustration of inappropriate spiral artery remodeling and abnormal placental angiogenesis in the presence of A2M overexpression. b, b1 Western blotting data showing the expression of HIF-1α in the control, A2M-overexpression, and A2M-downregulated groups (b), and b1 shows the quantitative analysis of HIF-1α expression in the three groups. c, d ELISA data showing the sFLT-1 (c) and PIGF (d) levels in human maternal serum obtained from the first, second, and third trimesters of pregnancy in the normal and PE groups. e, f ELISA data showing the sFLT-1 (e) and PIGF (f) levels in maternal rat serum at GD7.5 and GD19.5 in the control and A2M-overexpression groups. *P < 0.05, ***P < 0.001

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BMC Medicine

ISSN: 1741-7015

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