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Table 2 Clinical and laboratory characteristics of the study population

From: Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

Variables

Normal

n=53

PE

n=52

P-value

Gestational age at diagnosis in weeks

—

30.3±0.5

—

Maternal age (years)

30.3±0.5

30.9±0.7

0.562

Weight (kg)

66.2±1.2

69.5±1.8

0.142

Height (cm)

160.8±0.8

155.8±3.2

0.129

BMI (kg/m2)

25.6±0.4

27.6±0.4

0.019**

Systolic blood pressure (mmHg)

116.6±1.4

163.5±2.1

<0.001***

Diastolic blood pressure (mmHg)

73.5±1.1

102.0±1.4

<0.001***

MAP (mmHg)

87.8±1.0

123.1±1.5

<0.001***

Gestational weeks at delivery (week)

39.3±0.1

37.0±0.4

<0.001***

Proteinuria (g/24 h)

—

1.0±0.1

—

Platelet count (×10^9/L)

210.0±6.9

193.1±7.7

0.105

Birthweight (kg)

3.2±0.5

2.4±0.1

<0.001***

Umbilical cord length (cm)

50.6±1.0

45.88±1.3

0.004**

Amniotic fluid volume (ml)

547.7±39.9

467.9±20.5

0.079

Placental weight (g)

555.2±8.7

466.9±14.0

<0.001***

Cesarean section rate (n, %)

16 (30.2)

42 (80.8)

<0.001***

Maternal adverse outcomes (n, %)

1 (1.9)

15 (35.7)

<0.001***

 Placental abruption (n, %)

0 (0.0)

3 (7.1)

0.076

 PPH (n, %)

1 (1.9)

2 (4.8)

0.547

 Eclampsia (n, %)

0 (0.0)

0 (0.0)

—

 Incomplete uterine rupture (n, %)

0 (0.0)

2 (4.8)

0.149

 Cardiac insufficiency (n, %)

0 (0.0)

1 (1.9)

0.310

 Fetal/neonatal adverse outcomes (n, %)

4 (7.5)

30 (57.7)

<0.001***

 Preterm birth (<37 weeks) (n, %)

0 (0.0)

16 (30.8)

<0.001***

 LBW (n, %)

0 (0.0)

15 (28.8)

<0.001***

 Myocardial damage (n, %)

1 (1.9)

13 (25.0)

<0.001***

 PFO (n, %)

1 (1.9)

8 (15.4)

0.014*

 Hypoalbuminemia (n, %)

0 (0.0)

16 (30.8)

<0.001***

 Neonatal anemia (n, %)

0 (0.0)

9 (17.3)

0.002**

 Neonatal hyperbilirubinemia (n, %)

3 (5.7)

15 (28.0)

0.002**

  1. Differences between the groups were compared with the Mann–Whitney U test or chi-square test or Fisher’s exact test; *P<0.05, **P<0.01, ***P<0.001. PE, pre-eclampsia; weight, the maternal weight in the first day of the latest hospital admission (usually occur within a week before delivery); BMI, body mass index; MAP, mean arterial pressure; PPH, postpartum hemorrhage; LBW, low-birth-weight infant; PFO, patent foramen ovale. Values are mean ± S.E.M