Table 1 Descriptive characteristics of women with inflammatory bowel disease (IBD), and their neonates exposed to corticosteroids during pregnancy, and unexposed from 1995 to 2015*
Exposed cohort #1 N = 707 | Exposed cohort #2 N = 1336 | Unexposed cohort N = 9371 | |
|---|---|---|---|
Maternal age at child birth, median years (25–75 percentiles) | 31 (28–34) | 30 (28–34) | 31 (28–34) |
Maternal underlying disease, N (%) | |||
Ulcerative colitis | 477 (67.5) | 963 (72.1) | 5404 (57.7) |
Crohn’s disease | 228 (32.2) | 367 (27.5) | 3916 (41.8) |
Both diagnosis | 2 (0.3) | 6 (0.4) | 51 (0.5) |
Maternal disease duration, median years (25–75 percentiles) | 5 (2–10) | 4 (1–8) | 6 (3–11) |
Maternal BMI1, N (%) | |||
< 18.5 (underweight) | 25 (3.5) | 50 (3.7) | 313 (3.3) |
18.5–24.99 (normal weight) | 278 (39.3) | 512 (38.3) | 3904 (41.7) |
25.00–29.99 (overweight) | 81 (11.5) | 160 (12.0) | 1215 (13.0) |
> 30.00 (obese) | 41 (5.8) | 94 (7.0) | 710 (7.6) |
Missing | 282 (39.9) | 520 (38.9) | 3229 (34.5) |
Maternal smoking, N (%) | |||
Non-smoker | 564 (79.8) | 1065 (79.7) | 7389 (78.8) |
Smoker | 79 (11.2) | 156 (11.7) | 1444 (15.4) |
Missing | 64 (9.1) | 115 (8.6) | 538 (5.7) |
Maternal comorbidity, N (%) | |||
No comorbidity | 604 (85.4) | 1169 (87.5) | 8371 (89.3) |
Some comorbidity | 103 (14.6) | 167 (12.5) | 1000 (10.7) |
Biologic therapy**,*** | |||
No | 684 (96.7) | 1288 (96.4) | 9154 (97.7) |
Yes | 23 (3.3) | 48 (3.6) | 217 (2.3) |
Azathioprine/mercaptopurine*** | |||
No | 616 (87.1) | 1192 (89.2) | 8816 (94.1) |
Yes | 91 (12.9) | 144 (10.8) | 555 (5.9) |
5-ASA*** | |||
No | 242 (34.2) | 403 (30.2) | 6731 (71.8) |
Yes | 465 (65.8) | 933 (69.8) | 2640 (28.2) |
Methotrexate*** | |||
No | 707 (100.0) | 1335 (99.9) | 9370 (100.0) |
Yes | 1 (0.1) | 1 (0.0) | |
Calendar year of childbirth, N (%) | |||
1995–1999 | 123 (17.4) | 254 (19.0) | 1513 (16.1) |
2000–2004 | 184 (26.0) | 303 (22.7) | 1966 (21.0) |
2005–2009 | 181 (25.6) | 387 (29.0) | 2426 (25.9) |
2010–2015 | 219 (31.0) | 392 (29.3) | 3466 (37.0) |
Parity, N (%) | |||
0 | 318 (45.0) | 657 (49.2) | 4442 (47.4) |
1 + | 389 (55.0) | 679 (50.8) | 4929 (52.6) |
Sex of the child, N (%) | |||
Female | 345 (48.8) | 656 (49.1) | 4609 (49.2) |
Male | 362 (51.2) | 680 (50.9) | 4762 (50.8) |
Maternal diagnoses, N (%) | |||
O47 False labor | 37 (5.2) | 71 (5.3) | 528 (5.6) |
Z358B Previous preterm birth | 20 (2.8) | 32 (2.4) | 227 (2.4) |
P05-08 Intrauterin growth retardation | 4 (0.0) | ||
O14 Pre-eclampsia | 26 (3.7) | 40 (3.0) | 290 (3.1) |
O45 Abruptio placentae | 5 (0.7) | 9 (0.7) | 56 (0.6) |
O244 Gestational diabetes mellitus | 19 (2.7) | 39 (2.9) | 211 (2.3) |