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Table 4 Multivariable Cox proportional hazard regression model with crude and adjusted estimates and 95% confidence intervals (CI) and the hazard ratios for hospitalization with infection, and first time infection, in live born children exposed in utero to corticosteroids (#2), relative to children not exposed in utero to corticosteroids

From: Adverse birth outcomes and early-life infections after in utero exposure to corticosteroids for inflammatory bowel disease: a Danish nationwide cohort study

 

Live births after in utero exposure to corticosteroids #2

N = 1336

Live births not exposed in utero to corticosteroids

N = 9371

Hazard ratios (95% CI)

Groups of child infections, 0–1 year

N events

Years at risk

N events

Years at risk

Crude

Adjusteda

First infection (any kind)

193

1234.2

1406

8614.2

0.96 (0.82–1.11)

1.14 (0.94–1.39)

Respiratory

111

1274.9

709

8972.8

1.10 (0.90–1.35)

1.18 (0.91–1.54)

Gastrointestinal

31

1318.3

273

9212.4

0.79 (0.55–1.15)

1.04 (0.66–1.63)

Urological/gynecological

9

1325.6

61

9302.8

1.04 (0.52–2.06)

1.69 (0.73–3.92)

Skin/subcutaneous tissue

-

1329.6

-

9333.3

-

-

Bacteremia

-

1328.0

17

9321.7

-

-

Other infections

80

1293.1

633

9033.1

0.88 (0.70–1.12)

1.23 (0.93–1.64)

  1. aAdjusted for maternal comorbidity, maternal age at child birth, preterm birth, small for gestational age, calendar year of child birth, maternal smoking status, parity, sex of the child, maternal BMI, maternal use of biologic therapy, azathioprines, or 5-ASA 30 days prior to conception or during pregnancy