Table 1 Disease burden and healthcare costs used for model comparison exercise
Input parameter | Value | Source |
|---|---|---|
RSV disease event rates per 100,000 per year (< 5yrs) | ||
 RSV non-severe cases | ||
  Low income | 4450 | Li 2022 [1] |
  Lower middle income | 3740 | Li 2022 [1] |
  Upper middle income | 4830 | Li 2022 [1] |
 RSV severe cases | ||
  Low income | 480 | Li 2022 [1] |
  Lower middle income | 1400 | Li 2022 [1] |
  Upper middle income | 690 | Assume 1/8 of all RSV-ALRI cases in Li 2022 [1] |
 RSV clinic visits | ||
  Low income | 2642 | RSV cases × 53.6% treatment for pneumonia [59] |
  Lower middle income | 3395 | RSV cases × 66.0% treatment for pneumonia [59] |
  Upper middle income | 3949 | RSV cases × 71.5% treatment for pneumonia [59] |
 RSV hospital admissions | ||
  Low income | 350 | Li 2022 [1] |
  Lower middle income | 620 | Li 2022 [1] |
  Upper middle income | 620 | Li 2022 [1] |
 RSV deaths | ||
  Low income | 29.86 | Li 2022 [1] |
  Lower middle income | 19.76 | Li 2022 [1] |
  Upper middle income | 4.73 | Li 2022 [1] |
Cumulative percentage of RSV severe cases < 5 years, by age * | ||
 1 m | 3.91% | A Burr distribution was fitted to RSV hospital admission data from two unpublished datasets (Argentina and Vietnam) and four studies (Kenya [45], Mozambique [46], Pakistan [47], and South Africa [48]) identified in Li, 2022 [1] |
 3 m | 35.60% | |
 6 m | 59.53% | |
 1 yr | 77.21% | |
 2yrs | 89.48% | |
 5yrs | 100.00% |  |
Cumulative percentage of RSV non-severe cases < 5 years, by age** | ||
 1 m | 0.29% | The ratio of non-severe to severe RSV case incidence from Li, 2022 [1] was applied in broad age bands (< 3 m, 3–5 m, 6–11 m, 12–59 m) to the fitted Burr age distribution for severe RSV cases. An updated Burr age distribution was then fitted to non-severe RSV cases |
 3 m | 10.65% | |
 6 m | 37.90% | |
 1 yr | 65.85% | |
 2yrs | 84.91% | |
 5yrs | 100.00% | |
DALY weights | ||
 RSV non-severe cases | 0.051 | GBD, 2019 [49] |
 RSV severe cases | 0.133 | GBD, 2019 [49] |
Duration of illness (days) | ||
 RSV non-severe cases | 5 | Hall et al. [60] − / + 2 days |
 RSV severe cases | 10 | Hall et al. [60] − / + 2 days |
Healthcare costs (US$) | ||
 RSV clinic visits | 62.24 | Cost of managing pneumonia, Zhang et al. [51] |
 RSV hospital admissions | 368.42 | Cost of managing pneumonia, Zhang et al. [51] |