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Table 2 Associations of serum biomarkers and cardiac measures with EAT thickness

From: Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain

 

β (standard error)

Crude

P

Adjusteda

P

Biomarkers, log pg/mL

 CRP

0.20 (0.03)

 < 0.001

0.06 (0.03)

0.030

 LEP

0.15 (0.03)

 < 0.001

0.08 (0.02)

0.001

 GDF15

0.05 (0.01)

 < 0.001

0.02 (0.01)

0.039

 MMP8

0.10 (0.02)

 < 0.001

0.05 (0.02)

0.035

 MMP9

0.06 (0.01)

 < 0.001

0.03 (0.01)

0.036

 ORM1

0.04 (0.01)

 < 0.001

0.02 (0.01)

0.003

 ANGPTL3

0.06 (0.01)

 < 0.001

0.02 (0.01)

0.023

 SERPINE1

0.12 (0.01)

 < 0.001

0.04 (0.01)

0.001

 NT-proBNP

 − 0.11 (0.02)

 < 0.001

 − 0.09 (0.02)

 < 0.001

 IGFBP1

 − 0.24 (0.02)

 < 0.001

 − 0.09 (0.02)

 < 0.001

 IGFBP2

 − 0.09 (0.01)

 < 0.001

 − 0.04 (0.01)

0.005

 AGER

 − 0.07 (0.01)

 < 0.001

 − 0.04 (0.01)

 < 0.001

 CNTN1

 − 0.04 (0.01)

 < 0.001

 − 0.02 (0.01)

0.010

 MCAM

 − 0.02 (0.01)

0.001

 − 0.02 (0.01)

0.018

Cardiac measures

 LVEDD, mm

0.40 (0.12)

0.001

 − 0.23 (0.11)

0.040

 LAID, mm

1.46 (0.13)

 < 0.001

0.19 (0.12)

0.10

 LVWT (septal), mm

0.29 (0.03)

 < 0.001

0.07 (0.03)

0.029

 LVWT (inferior), mm

0.30 (0.03)

 < 0.001

0.09 (0.03)

0.002

 LVEF, %

0.26 (0.17)

0.12

0.36 (0.17)

0.06

 GLS, %

0.63 (0.09)

 < 0.001

0.34 (0.09)

 < 0.001

 E/é

0.13 (0.06)

0.025

0.02 (0.06)

0.69

  1. Biomarker description: CRP, C-reactive protein; LEP, leptin; GDF15, growth differentiation factor 15; MMP8, matrix metallopeptidase 8; MMP9, matrix metallopeptidase 9; ORM1, orosomucoid 1; ANGPTL3, angiopoietin-like 3; SERPINE1, serpin family E member 1; NT-proBNP, N-terminal pro-B-type natriuretic peptide; IGFBP1, insulin-like growth factor-binding protein 1; IGFBP2, insulin-like growth factor-binding protein 2; AGER, advanced glycation end products; CNTN1, contactin 1; MCAM, melanoma cell adhesion molecule
  2. Abbreviations: LVEDD left ventricular end-diastolic dimension, LAID left atrial internal dimension, LVWT left ventricular wall thickness, LVEF left ventricular ejection fraction, GLS global longitudinal strain, E/é mitral inflow velocity to early diastolic mitral annular velocity
  3. aAdjusted for sex, age, body mass index, systolic blood pressure, diastolic blood pressure, estimated glomerular filtration rate, diabetes mellitus, atrial fibrillation, coronary heart disease, and dyslipidemia
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BMC Medicine

ISSN: 1741-7015

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