Fig. 5
Comparisons between MR estimates inferred from all IVs and IVs outside the MHC region. Scatter plot of the Z statistics of MR estimates of traits showing suggestive causal evidence with anti-VZV IgG levels using IVs outside MHC region (IVno.mhc, vertical axis) or all IVs (IVfull, horizontal axis). A–E Results inferred from one MR method, with blue and orange dots indicating consistent (in the same causal directions) or inconsistent (in the opposite causal directions) MR results separately. F The combined MR results inferred from different methods, which are suggested by different colours. The dashed lines are the 95% confidence interval (CI) of Z statistics. Dots outside the CI are statistically significant (P < 0.05) MR results. The annotation on the bottom-left of each figure shows the Spearman correlation estimate (cor) and P-value of the correlation test. The legend on the bottom-right of each figure represents the number of the results that are statistically consistent (con) and statistically inconsistent (incon)