Table 2 MR results of traits causally affected by anti-VZV IgG levels
Phenotype description | Sample size | Case | Control | Source | IV | IVW | MR-Egger | MR-PRESSO | MR-RAPS | Weighted median | |||||
Beta | FDR | Beta | FDR | Beta | FDR | Beta | FDR | Beta | FDR | ||||||
Age hay fever or allergic rhinitis diagnosed by a doctor | 20,904 | NA | NA | phesant | IVmhc |  − 0.282 | 0.045 |  − 0.461 | 0.979 |  − 0.29 | 0.329 |  − 0.297 | 0.002 |  − 0.335 | 0.01 |
Sensitivity analysis |  − 0.345 | 0.004 | NA | NA | NA | NA |  − 0.346 | 0.004 | NA | NA | |||||
Body fat percentage | 354,628 | NA | NA | phesant | IVmhc | 0.07 | 0.043 | 0.023 | 0.994 | 0.08 | 0.359 | 0.085 | 0 | 0.062 | 0.017 |
Sensitivity analysis | 0.059 | 0.011 | NA | NA | NA | NA | 0.06 | 0.01 | NA | NA | |||||
Body mass index (BMI) | 359,983 | NA | NA | phesant | IVmhc | 0.105 | 0.027 | 0.197 | 0.979 | 0.119 | 0.332 | 0.127 | 0 | 0.099 | 0.002 |
Sensitivity analysis | 0.099 | 0.001 | NA | NA | NA | NA | 0.105 | 0 | NA | NA | |||||
Forced expiratory volume in 1-s (FEV1), predicted percentage | 117,241 | NA | NA | phesant | IVmhc |  − 0.246 | 0.019 |  − 0.197 | 0.979 |  − 0.264 | 0.326 |  − 0.279 | 0 |  − 0.262 | 0 |
Sensitivity analysis |  − 0.26 | 0 | NA | NA | NA | NA |  − 0.261 | 0 | NA | NA | |||||
Number of incorrect matches in round | 360,686 | NA | NA | phesant | IVmhc |  − 0.082 | 0.01 |  − 0.057 | 0.979 |  − 0.084 | 0.326 |  − 0.085 | 0 |  − 0.087 | 0.002 |
Sensitivity analysis |  − 0.101 | 0 | NA | NA | NA | NA |  − 0.101 | 0 | NA | NA | |||||
Peak expiratory flow (PEF) | 329,404 | NA | NA | phesant | IVmhc |  − 0.122 | 0 |  − 0.06 | 0.979 |  − 0.129 | 0.301 |  − 0.133 | 0 |  − 0.109 | 0 |
Sensitivity analysis |  − 0.126 | 0 | NA | NA | NA | NA |  − 0.138 | 0 | NA | NA | |||||
Trunk fat mass | 354,597 | NA | NA | phesant | IVmhc | 0.119 | 0.043 | 0.27 | 0.979 | 0.132 | 0.329 | 0.15 | 0 | 0.144 | 0 |
Sensitivity analysis | 0.128 | 0 | NA | NA | NA | NA | 0.131 | 0 | NA | NA | |||||
Trunk fat percentage | 354,619 | NA | NA | phesant | IVmhc | 0.085 | 0.019 | 0.053 | 0.979 | 0.096 | 0.335 | 0.102 | 0 | 0.066 | 0.031 |
Sensitivity analysis | 0.077 | 0.005 | NA | NA | NA | NA | 0.078 | 0.004 | NA | NA | |||||
Whole body fat mass | 354,244 | NA | NA | phesant | IVmhc | 0.112 | 0.043 | 0.257 | 0.979 | 0.108 | 0.329 | 0.139 | 0 | 0.113 | 0.001 |
Sensitivity analysis | 0.116 | 0 | NA | NA | NA | NA | 0.121 | 0 | NA | NA | |||||
| Â | Â | Â | Â | Â | Â | Odds ratio | Â | Odds ratio | Â | Odds ratio | Â | Odds ratio | Â | Odds ratio | Â |
Carpal tunnel syndrome | 361,194 | 7973 | 353,221 | finngen | IVmhc | 1.014 | 0.045 | 1.022 | 0.979 | 1.014 | 0.329 | 1.015 | 0 | 1.015 | 0.007 |
Sensitivity analysis | 1.017 | 0 | NA | Â | NA | Â | 1.018 | 0 | NA | Â | |||||
Diagnoses—main ICD10: G56 mononeuropathies of upper limb | 361,194 | 8130 | 353,064 | icd10 | IVmhc | 1.016 | 0.011 | 1.026 | 0.979 | 1.016 | 0.326 | 1.017 | 0 | 1.015 | 0.008 |
Sensitivity analysis | 1.019 | 0 | NA | Â | NA | Â | 1.02 | 0 | NA | Â | |||||
Diagnoses—main ICD10: K40 Inguinal hernia | 361,194 | 13,147 | 348,047 | icd10 | IVmhc | 0.986 | 0.047 | 0.965 | 0.979 | 0.985 | 0.329 | 0.985 | 0 | 0.985 | 0.025 |
Sensitivity analysis | 0.982 | 0.001 | NA | Â | NA | Â | 0.982 | 0.001 | NA | Â | |||||
Doctor diagnosed sarcoidosis | 91,787 | 395 | 91,392 | phesant | IVmhc | 1.018 | 0.043 | 1.04 | 0.979 | 1.02 | 0.328 | 1.021 | 0 | 1.023 | 0 |
Sensitivity analysis | 1.025 | 0 | NA | Â | NA | Â | 1.025 | 0 | NA | Â | |||||
Guilty feelings | 351,907 | 100,128 | 251,779 | phesant | IVmhc | 0.967 | 0.045 | 0.966 | 0.979 | 0.966 | 0.329 | 0.965 | 0.001 | 0.957 | 0.002 |
Sensitivity analysis | 0.956 | 0.001 | NA | Â | NA | Â | 0.956 | 0.001 | NA | Â | |||||
Long-standing illness, disability or infirmity | 352,798 | 114,798 | 238,000 | phesant | IVmhc | 1.075 | 0.043 | 1.099 | 0.979 | 1.094 | 0.326 | 1.098 | 0 | 1.076 | 0 |
Sensitivity analysis | 1.066 | 0 | NA | Â | NA | Â | 1.079 | 0 | NA | Â | |||||
Mouth/teeth dental problems: dentures | 359,841 | 60,977 | 298,864 | phesant | IVmhc | 1.048 | 0.01 | 1.118 | 0.979 | 1.052 | 0.326 | 1.055 | 0 | 1.052 | 0.001 |
Sensitivity analysis | 1.051 | 0 | NA | Â | NA | Â | 1.059 | 0 | NA | Â | |||||
Non-cancer illness code, self-reported: diabetic eye disease | 361,141 | 699 | 360,442 | phesant | IVmhc | 1.004 | 0.001 | 1.006 | 0.979 | 1.004 | 0.301 | 1.004 | 0 | 1.005 | 0 |
Sensitivity analysis | 1.004 | 0.001 | NA | Â | NA | Â | 1.004 | 0.001 | NA | Â | |||||
Non-cancer illness code, self-reported: malabsorption/coeliac disease | 361,141 | 1587 | 359,554 | phesant | IVmhc | 1.034 | 0.045 | 1.12 | 0.979 | 1.036 | 0.484 | 1.075 | 0 | 1.029 | 0 |
Sensitivity analysis | 1.044 | 0 | NA | Â | NA | Â | 1.084 | 0 | NA | Â | |||||
Other serious medical condition/disability diagnosed by a doctor | 354,588 | 72,965 | 281,623 | phesant | IVmhc | 1.047 | 0.043 | 1.119 | 0.979 | 1.051 | 0.329 | 1.053 | 0 | 1.057 | 0 |
Sensitivity analysis | 1.045 | 0 | NA | Â | NA | Â | 1.054 | 0 | NA | Â | |||||
Other specific joint derangements/joint disorders | 361,194 | 7943 | 353,251 | finngen | IVmhc | 1.009 | 0.05 | 1.008 | 0.979 | 1.009 | 0.326 | 1.01 | 0.011 | 1.011 | 0.022 |
Sensitivity analysis | 1.01 | 0.042 | NA | Â | NA | Â | 1.01 | 0.04 | NA | Â | |||||
Palmar fascial fibromatosis [Dupuytren] | 361,194 | 2948 | 358,246 | finngen | IVmhc | 1.007 | 0.01 | 1.006 | 0.979 | 1.007 | 0.325 | 1.007 | 0 | 1.007 | 0.027 |
Sensitivity analysis | 1.007 | 0.02 | NA | Â | NA | Â | 1.007 | 0.022 | NA | Â | |||||
Tense/ ‘highly strung’ | 350,159 | 60,513 | 289,646 | phesant | IVmhc | 0.968 | 0.043 | 0.956 | 0.979 | 0.966 | 0.329 | 0.965 | 0 | 0.965 | 0.005 |
Sensitivity analysis | 0.964 | 0.001 | NA | Â | NA | Â | 0.963 | 0.001 | NA | Â | |||||