Table 2 The difference in cumulative incidence of medical complaints for up to 90 days after 3rd dose mRNA vaccine vs no 3rd dose mRNA vaccine per 100,000 vaccinated

Fatigue

 45 years

1714

2 172

458 (355, 539)

21%

  < 45 years, with R992

94

196

102 (76, 125)

52%

  ≥ 45 years

1293

1 788

495 (364, 614)

28%

  ≥ 45 years, with R992

62

187

125 (90, 154)

67%

Musculoskeletal pain

  < 45 years

3438

3 609

171 (48, 292)

5%

  < 45 years, with R992

26

58

32 (18, 45)

55%

  ≥ 45 years

4976

4 797

 − 179 (− 419, 26)

 − 4%

  ≥ 45 years, with R992

30

63

33 (9, 54)

52%

Cough

  < 45 years

564

682

118 (65, 173)

17%

  < 45 years, with R992

42

72

30 (14, 45)

42%

  ≥ 45 years

705

1001

296 (191, 389)

30%

  ≥ 45 years, with R992

44

103

59 (31, 87)

57%

Heart palpitations

  < 45 years

247

304

57 (22, 98)

20%

  < 45 years, with R992

6

14

8 (1, 16)

57%

  ≥ 45 years

306

375

69 (14, 132)

18%

  ≥ 45 years, with R992

3

7

4 (− 4, 9)

57%

Shortness of breath

  < 45 years

204

322

118 (81, 149)

37%

  < 45 years, with R992

17

53

36 (22, 48)

68%

  ≥ 45 years

287

463

176 (100, 240)

38%

  ≥ 45 years, with R992

11

67

56 (38, 76)

84%

Brain fog

  < 45 years

91

122

31 (8, 53)

25%

  < 45 years, with R992

2

5

3 (− 1, 8)

60%

  ≥ 45 years

80

101

21 (− 10, 52)

21%

  ≥ 45 years, with R992

2

3

1 (− 3, 5)

33%

First/any complaint

  < 45 years

5989

6802

813 (678, 975)

12%

  < 45 years, with R992

179

368

189 (149, 227)

51%

  ≥ 45 years

7349

8015

666 (443, 941)

8%

  ≥ 45 years, with R992

145

403

258 (205, 308)

64%