Skip to main content
Fig. 4 | BMC Medicine

Fig. 4

From: Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Fig. 4

SMR and colocalization analyses prioritized intestinal causal OS genes and interactions with gut microbial pathways in CD. The left panels indicate the SMR between gene expressions and CD GWAS (all SMR FDR < 0.05; HEIDI test P > 0.05), while the right panels show the locus comparisons between cis-eQTLs and mbQTLs by colocalization analysis (all PPH4 > 0.5). The r 2 value indicates the linkage disequilibrium (LD) between the variants and the top SNPs. A–C The genes of MUC1, CD40, and PRKAB1, respectively

Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us