Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis

Table 2 Serum metabolites associated with child overweight/adiposity at age 5 years in CHILD^a

Metabolite	OR	95% CI	p-	FDR
Leucine	1.28	(1.07–1.54)	0.007	0.009
BCAAs	1.27	(1.06–1.52)	0.009	0.018
Valine	1.26	(1.06–1.51)	0.01	0.027
AAAs	1.23	(1.03–1.48)	0.024	0.036
Isoleucine	1.23	(1.03–1.47)	0.025	0.045
Glutamic acid	1.28	(1.04–1.61)	0.025	0.054
Threonine	1.23	(1.02–1.47)	0.029	0.063
Glutamine/glutamic acid	0.81	(0.66–0.98)	0.039	0.072
Phenylalanine	1.22	(1.01–1.47)	0.042	0.082
Tyrosine	1.19	(1.00–1.42)	0.045	0.09
Oxoproline	1.22	(1.01–1.48)	0.045	0.1

BCAAs branched-chain amino acids, AAAs aromatic amino acids, OR odds ratio, 95% CI confidence intervals, p- p-value for statistical significance, FDR false discovery rate d = 0.1; when p- is smaller than this value, association passes multiple hypothesis testing
^aMultivariable logistic regression adjusting for maternal education, sleep time, breastfeeding status at 1 year, sex, and age [204 (23%) had missing values on at least one covariate; complete cases analysis n = 696: 173 cases and 523 non-cases]

ISSN: 1741-7015