Fig. 7

Piericidin diglycoside S18 protects the aortic valve against injury in an established CAVD model. Echocardiographic data in wire injury-induced CAVD moues model. A-B Peak transvalvular jet velocity, aortic valve peak pressure, and AVA. C-D Images of aortic valves in the aortic valve calcification model. H&E staining of aortic valves after wire injury. Scale bar = 200 μm. E Masson’s trichrome staining. Scale bar = 50 μm, F Von Kossa staining. Scale bar = 50 μm. G-H Immunofluorescence images of the aortic valve (DAPI: blue, WGA: green). Scale bar = 50 μm. n = 5. All data are the means ± SEM. #p < 0.05, vs. the sham group, *p < 0.05 vs. the AVI and S18 group