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Fig. 1 | BMC Medicine

Fig. 1

From: miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Fig. 1

Increased abundance of tissue sEV miR-142-3p is correlated with clinical features of HT. A–C Tissue sEVs were validated by NTA, TEM (scale bar, 100 nm), and WB. D The top five tissue sEV miRNAs expressed in all testing samples. E Two tissue sEV miRNAs were further confirmed by qRT‒PCR in a validation set. F Tissue sEV miR-142-3p was positively associated with the levels of TgAb and TPOAb. G Higher tissue sEV miR-142-3p was accompanied by more severe lymphocyte infiltration in thyroid tissue, scale bar, 100 μm. H ROC curve showed that tissue sEV miR-142-3p achieved an AUC of 0.838

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BMC Medicine

ISSN: 1741-7015

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