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Fig. 2 | BMC Medicine

Fig. 2

From: miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Fig. 2

Tissue sEV miR-142-3p was derived from T lymphocytes and can be transferred to thyrocyte cells. A HT tissue showed more immune cell-derived sEVs, scale bar, 10 μm. B miR-142-3p is highly abundant in T lymphocytes, especially T lymphocytes isolated from HT patients. C–E T lymphocyte-derived sEVs were validated by NTA, TEM (scale bar, 100 nm) and WB. F Confocal microscopy showed that thyrocyte cells can internalize green-labeled T lymphocyte-derived sEVs, scale bar, 20 μm. G The expression of miR-142-3p was higher in thyrocyte cells incubated with sEVs than in thyrocyte cells incubated with PBS. H FISH showed that miR-142-3p was minimally detected in the thyroid glands of healthy controls but abundantly detected in the thyroid glands of patients with HT, scale bar, 50 μm

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BMC Medicine

ISSN: 1741-7015

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