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Fig. 3 | BMC Medicine

Fig. 3

From: miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Fig. 3

MiR-142-3p highly expressed in T lymphocytes can induce Treg function defects. A Higher tissue sEV miR-142-3p levels were accompanied by fewer Treg cells in HT tissue, scale bar, 100 μm. B Higher miR-142-3p in T lymphocytes indicated less Foxp3 expression. C The induced expression of miR-142-3p in T lymphocytes inhibits Treg differentiation. D miR-142-3p has no effect on the proliferation of Treg cells. E Apoptosis of Treg cells was significantly increased after treatment with mimics and decreased after treatment with inhibitor. F Cytokine experiments showed that overexpression of miR-142-3p resulted in significant decreases in secretion of the anti-inflammatory factors TGF-β and IL-10

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BMC Medicine

ISSN: 1741-7015

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