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Fig. 4 | BMC Medicine

Fig. 4

From: miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Fig. 4

T lymphocyte-derived tissue sEV miR-142-3p promotes thyrocyte destruction. A Colony formation assays showed that miR-142-3p suppressed thyrocyte cell proliferation. B Flow cytometry suggested that mimic-treated thyrocytes underwent a significant increase in apoptosis, whereas the inhibition of miR-142-3p decreased the apoptosis of thyrocytes. C Mimic-treated thyrocyte cells can secrete more CXCL9/11, whereas the inhibition of miR-142-3p decreased the secretion of CXCL9/11. D The size of the organoid decreased after transfection with the miR-142-3p mimics and increased after transfection with the inhibitor; scale bar, 100 μm. E Apoptosis was increased in organoids after transfection with the mimics and decreased after transfection with the inhibitor. F The chemokine assay showed that mimic-treated thyroid organoids secreted more CXCL9/11. In contrast, the miR-142-3p inhibitor decreased the secretion of CXCL9/11

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BMC Medicine

ISSN: 1741-7015

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