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Fig. 5 | BMC Medicine

Fig. 5

From: miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Fig. 5

MiR-142-3p regulated the ERK1/2 pathway by targeting RAC1 in thyrocyte cells. A qRT‒PCR showed that the level of RAC1 mRNA was significantly decreased in HT tissue compared with normal tissue. B Dual luciferase reporter assays showed that miR-142-3p could significantly reduce wild-type RAC1 luciferase activity. C WB analysis showed that miR-142-3p could inhibit RAC1 expression at the protein level. D–F Downregulation of RAC1 expression effectively reverses miR-142-3p inhibitor-induced apoptosis, proliferation, and secretion of CXCL9/11 in thyrocyte cells. G WB analysis showed that miR-142-3p regulates ERK1/2 pathway-related proteins via RAC1

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BMC Medicine

ISSN: 1741-7015

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