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Fig. 6 | BMC Medicine

Fig. 6

From: miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis

Fig. 6

Injection of miR-142-3p sponge prevents HT development in NOD. H-2.h4 mice. A The mode diagram of LV administration. B The scoring of thyroid inflammation in the LV-sponge group was significantly decreased, scale bar, 100 μm. C The serum TgAb and TPOAb titers of the LV-sponge group were significantly lower than those of the LV-ctrl group. D IHC showed that the Treg cells in the LV-sponge group were higher than those in the LV-ctrl group in the thyroid, scale bar, 50 μm. E The mice treated with LV-sponge exhibited a higher Treg percentage than control mice. F Caspase3 expression level in thyroid was decreased, but the protein levels of RAC1 and p-ERK1/2 were increased after treatment with LV-sponge compared with LV-ctrl; G Schematic diagram (①: MiR-142-3p highly expressed in T lymphocytes induces Treg function defect; ②: T lymphocyte-derived tissue sEV miR-142-3p promotes thyrocyte destruction through the RAC1-mediated ERK1/2 signal)

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BMC Medicine

ISSN: 1741-7015

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