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Fig. 2 | BMC Medicine

Fig. 2

From: Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study

Fig. 2

Brain regions with significant morphological alterations compared to the healthy controls in externalizing disorders group, internalizing disorders group, and the comorbidity group. The brain regions with significant morphological differences compared to the healthy controls in externalizing disorders group (A, B), internalizing disorders group (C, D), and comorbidity (E, F) in terms of cortical surface area (A, C, E) and cortical thickness (B, D, F). The color bars in A–F represent the t value of the regression coefficient of the group variable from the linear mixed model (LMM). The regions with * represent p < 0.05, FDR corrected (FDR q = 0.05). The number of brain regions with significant alterations for each of the three transdiagnostic groups (externalizing, internalizing, and comorbidity groups) is shown for cortical surface area (G) and cortical thickness (H). Abbreviations: Int, internalizing disorders; Ext, externalizing disorders; Com, comorbid between internalizing and externalizing disorders; HC, healthy control

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BMC Medicine

ISSN: 1741-7015

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